Colorectal Cancer Incidence Rates by Age and Sex, 1998-2022, United States
This graph shows incidence rates (vertical axis) by sex for three age-groups (20 to 49; 50 to 64; 65 and over) from 1998 to 2022 (horizontal axis). Incidence rates are increasing among younger men and women (<65) and decreasing among older adults (65+). Source: Colorectal Cancer Statistics 2026 Slideshow
In 2026, an estimated 158,850 new cases of colorectal cancer (CRC) will be diagnosed, and 55,230 people will die from the disease in the United States.
The Alaska Native population has the highest CRC incidence (81 cases per 100,000 people) and death rates (32 deaths per 100,000) in the world—more than twice that of White people in the United States. The American Indian population has the second-highest CRC burden in the US.
Here are more key facts from the “Colorectal Cancer Statistics report, 2026,” published in the American Cancer Society (ACS) flagship journal CA: A Cancer Journal for Clinicians.
CRC is increasingly diagnosed in younger people (under age 65).
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